1st Dutch Antisense Therapeutics Symposium
December 3rd 2021, Leiden

9:30 - Arrival, Registration and Coffee 

9:55 - Welcome

10:00 National keynote lecture

          Annemieke Aartsma-Rus (LUMC): A brief history of exon-skipping therapy development: Developments in the current millennium.


10:45 Rick Wansink (Radboudumc) - Peptide-based delivery strategies for antisense oligonucleotides

11:15 Peter van den Akker (UMCG) - Exon-skipping therapy for dystrophic epidermolysis bullosa

11:45 Saskia A.J. Lesnik Oberstein (LUMC) - Skipping NOTCH3 exons to prevent protein aggregation in CADASIL patient arteries

11:45 Ype Elgersma (ErasmusMC) - Dutch Center for RNA Therapeutics


12:30 Lunch



13:15 Early Career Investigator Presentations* 

          13:15 To be announced after abstract selection

          13:30 To be announced after abstract selection

          13:45 To be announced after abstract selection

          14:00 To be announced after abstract selection

14:15 International Keynote Lecture:

          Bruno Godinho (Atlanta Therapeutics) Delivery of stabilized siRNA scaffolds to the central nervous system

15:00 Marjon Pasmooij (Medicines Evaluation Board) Antisense to medicine: a regulator’s perspective

15:30 Poster Pitches*

15:45 POSTER SESSION with Coffee and Cookies



17:00 Mike Schwartz (ProQR Therapeutics)Results of first-in-human clinical data of intravitreal sepofarsen (QR-110) antisense oligonucleotide in Leber congenital amaurosis type 10

17:30 Elizabeth Vroom (Duchenne Parent Project Netherlands) - The role of patient organizations in antisense oligonucleotide drug development

18:00 Awards, closing remarks

18:10 Drinks and Networking

19:30 Dinner (not included, pre-registration required)

*Deadline for abstract submission: November 17th 2021

*Announcement of the selected abstracts for presentation and poster pitches: November 19th 2021

Abstract book will be available digitally two weeks before the meeting.

For more info click here